Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein

Bourtchuladze, R., Frenguelli, B., Blendy, J., Cioffi, D., Schutz, G., Silva, A. J. (October 1994) Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein. Cell, 79 (1). pp. 59-68. ISSN 0092-8674 (Print)

DOI: 10.1016/0092-8674(94)90400-6


The cAMP-responsive element-binding protein (CREB) has been implicated in the activation of protein synthesis required for long-term facilitation, a cellular model of memory in Aplysia. Our studies with fear conditioning and with the water maze show that mice with a targeted disruption of the alpha and delta isoforms of CREB are profoundly deficient in long-term memory. In contrast, short-term memory, lasting between 30 and 60 min, is normal. Consistent with models claiming a role for long-term potentiation (LTP) in memory, LTP in hippocampal slices from CREB mutants decayed to baseline 90 min after tetanic stimulation. However, paired-pulse facilitation and posttetanic potentiation are normal. These results implicate CREB-dependent transcription in mammalian long-term memory.

Item Type: Paper
Uncontrolled Keywords: Animals Association Learning Conditioning (Psychology) Cyclic AMP Response Element-Binding Protein/genetics/ physiology Electrophysiology Female Hippocampus/physiology Long-Term Potentiation Male Memory/ physiology Mice Mice, Neurologic Mutants Mutation/ physiology Research Support, Non-U.S. Gov't
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor > Cyclic AMP
organism description > animal behavior > memory
CSHL Authors:
Communities: CSHL labs > Tully lab
Depositing User: Matt Covey
Date: 7 October 1994
Date Deposited: 27 Aug 2015 15:25
Last Modified: 27 Aug 2015 15:25
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