Gottipati, S., Arbiza, L., Siepel, A., Clark, A. G., Keinan, A. (August 2011) Analyses of X-linked and autosomal genetic variation in population-scale whole genome sequencing. Nat Genet, 43 (8). pp. 741-3. ISSN 1061-4036
Abstract
The ratio of genetic diversity on chromosome X to that on the autosomes is sensitive to both natural selection and demography. On the basis of whole-genome sequences of 69 females, we report that whereas this ratio increases with genetic distance from genes across populations, it is lower in Europeans than in West Africans independent of proximity to genes. This relative reduction is most parsimoniously explained by differences in demographic history without the need to invoke natural selection.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Chromosome Mapping Chromosomes, Human, X/*genetics Demography Female Genes, X-Linked/*genetics Genetic Variation/*genetics *Genetics, Population *Genome, Human Humans Selection, Genetic |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosome bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function > chromosome bioinformatics > genomics and proteomics > genetics & nucleic acid processing > genomes Investigative techniques and equipment > assays > whole genome sequencing |
| CSHL Authors: | |
| Communities: | CSHL labs > Siepel lab |
| Depositing User: | Matt Covey |
| Date: | August 2011 |
| Date Deposited: | 15 Jan 2015 17:03 |
| Last Modified: | 15 Jan 2015 17:03 |
| PMCID: | PMC3145052 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/31062 |
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