Corbo, V., Ponz-Sarvise, M., Tuveson, D. A. (September 2014) The RAS and YAP1 dance, who is leading? EMBO journal, 33 (21). pp. 3437-2438. ISSN 0261-4189
Abstract
The Hippo‐signaling effector YAP1 was recently found to compensate for oncogenic RAS in certain neoplasms, suggesting so far unanticipated molecular interplays between these major signaling routes. A new study in this issue of The EMBO Journal details KRAS‐dependent control of YAP1 stability as well as positive feedback regulation via the RAS/YAP1/EGFR‐ligand axis as novel molecular mechanisms that could become exploitable for therapeutic strategies.
| Item Type: | Paper |
|---|---|
| Subjects: | diseases & disorders > cancer bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > epidermal growth factor bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > G protein > Ras |
| CSHL Authors: | |
| Communities: | CSHL labs > Tuveson lab |
| Depositing User: | Matt Covey |
| Date: | 25 September 2014 |
| Date Deposited: | 05 Dec 2014 21:15 |
| Last Modified: | 16 Jul 2021 16:26 |
| PMCID: | PMC4283400 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/30963 |
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