Lisman, J., Malenka, R. C., Nicoll, R. A., Malinow, R.
(June 1997)
Learning mechanisms: the case for CaM-KII.
Science, 276 (5321).
pp. 2001-2.
Abstract
Long-term potentiation (LTP) is a strengthening of synapses in the brain that is thought to underlie learning and memory. Now in this issue Barria et al. show that the persistent change is likely to be phosphorylation of the postsynaptic glutamate receptor known as the AMPA receptor. Lisman et al. in their Perspective discuss how this phosphorylation may function to cause LTP and how these results fit in with other findings in the literature.
| Item Type: |
Paper
|
| Additional Information: |
0036-8075 (Print)
Journal Article |
| Uncontrolled Keywords: |
Animals
Ca(2+)-Calmodulin Dependent Protein Kinase/*metabolism
Hippocampus/metabolism
*Long-Term Potentiation
Memory
Mice
Mice, Transgenic
Phosphorylation
Phototransduction
Receptors, AMPA/*metabolism
Signal Transduction
Synapses/*metabolism
*Synaptic Transmission |
| Subjects: |
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > Long term potentiation
organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus
organism description > animal behavior > memory
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein expression > phosphorylation
organs, tissues, organelles, cell types and functions > tissues types and functions > signal transduction
organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse
organism description > animal behavior > vision |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Malinow lab |
| Depositing User: |
Kathleen Darby
|
| Date: |
27 June 1997 |
| Date Deposited: |
08 May 2014 14:30 |
| Last Modified: |
08 May 2014 14:30 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/30001 |
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