Sabatini, B. L., Oertner, T. G., Svoboda, K. (January 2002) The life cycle of Ca2+ ions in dendritic spines. Neuron, 33 (3). pp. 439-452. ISSN 0896-6273
Abstract
Spine Ca2+ is critical for the induction of synaptic plasticity, but the factors that control Ca2+ handling in dendritic spines under physiological conditions are largely unknown. We studied [Ca2+] signaling in dendritic spines of CA1 pyramidal neurons and find that spines are specialized structures with low endogenous Ca2+ buffer capacity that allows large and extremely rapid [Ca2+] changes. Under physiological conditions, Ca2+ diffusion across the spine neck is negligible, and the spine head functions as a separate compartment on long time scales, allowing localized Ca2+ buildup during trains of synaptic stimuli. Furthermore, the kinetics of Ca2+ sources governs the time course of [Ca2+] signals and may explain the selective activation of long-term synaptic potentiation (LTP) and long-term depression (LTD) by NMDA-R-mediated synaptic Ca2+.
| Item Type: | Paper |
|---|---|
| Subjects: | organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > calcium channel organs, tissues, organelles, cell types and functions > cell types and functions > cell functions organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells > dendritic spines organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells > dendritic spines organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells > dendritic spines organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > synaptic plasticity |
| CSHL Authors: | |
| Communities: | CSHL labs > Svoboda lab |
| Depositing User: | Matt Covey |
| Date: | January 2002 |
| Date Deposited: | 31 Oct 2013 15:53 |
| Last Modified: | 31 Oct 2013 15:53 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/28780 |
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