Patient-derived tumor xenografts: Transforming clinical samples into mouse models

Siolas, D., Hannon, G. J. (September 2013) Patient-derived tumor xenografts: Transforming clinical samples into mouse models. Cancer Research, 73 (17). pp. 5315-5319. ISSN 00085472 (ISSN)

DOI: 10.1158/0008-5472.can-13-1069


Tumor graft models (also known as patient-derived xenografts or PDX) are based on the transfer of primary tumors directly from the patient into an immunodeficient mouse. Because PDX mice are derived from human tumors, they offer a tool for developing anticancer therapies and personalizedmedicine for patients with cancer. In addition, these models can be used to study metastasis and tumor genetic evolution. This review examines the development, challenges, and broad use of these attractive preclinical models. ©2013 AACR.

Item Type: Paper
Subjects: diseases & disorders > cancer
diseases & disorders
organism description > model organism
CSHL Authors:
Communities: CSHL labs > Hannon lab
CSHL Cancer Center Program > Cancer Genetics
Depositing User: Matt Covey
Date: September 2013
Date Deposited: 15 Oct 2013 20:04
Last Modified: 14 Oct 2015 20:45
PMCID: PMC3766500
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