Sperry and Hebb: oil and vinegar?

Cline, H. (December 2003) Sperry and Hebb: oil and vinegar? Trends in Neurosciences, 26 (12). pp. 655-661. ISSN 0166-2236

Abstract

The interface between so-called activity-dependent and activity-independent mechanisms of circuit development is discussed here in light of recent findings that question the role of activity in brain development. This debate is presented simplistically here in terms of Sperry's chemoaffinity hypothesis versus Hebb's rules of correlation-based synaptic change, which are often presented as being mutually exclusive - much like oil and vinegar.

Item Type:	Paper
Uncontrolled Keywords:	OCULAR DOMINANCE COLUMNS LOCAL PROTEIN-SYNTHESIS SYNAPTIC PLASTICITY VISUAL-SYSTEM NMDA RECEPTOR GENETIC-ANALYSIS POLYSIALIC ACID NEURAL ACTIVITY AXON GUIDANCE N-CADHERIN
Subjects:	bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification bioinformatics > genomics and proteomics > genetics & nucleic acid processing organs, tissues, organelles, cell types and functions > organs types and functions > brain organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits organs, tissues, organelles, cell types and functions > organs types and functions organs, tissues, organelles, cell types and functions
CSHL Authors:	Cline, Hollis T.
Communities:	CSHL labs > Cline lab
Depositing User:	Matt Covey
Date:	December 2003
Date Deposited:	28 Mar 2013 14:22
Last Modified:	28 Mar 2013 14:22
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/28007

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