Circuit analysis of experience-dependent plasticity in the developing rat barrel cortex

Shepherd, G. M., Pologruto, T. A., Svoboda, K. (April 2003) Circuit analysis of experience-dependent plasticity in the developing rat barrel cortex. Neuron, 38 (2). pp. 277-89. ISSN 0896-6273 (Print)

Abstract

Sensory deprivation during a critical period reduces spine motility and disrupts receptive field structure of layer 2/3 neurons in rat barrel cortex. To determine the locus of plasticity, we used laser scanning photostimulation, allowing us to rapidly map intracortical synaptic connectivity in brain slices. Layer 2/3 neurons differed in their spatial distributions of presynaptic partners: neurons directly above barrels received, on average, significantly more layer 4 input than those above the septa separating barrels. Complementary connectivity was found in deprived cortex: neurons above septa were now strongly coupled to septal regions, while connectivity between barrel regions and layer 2/3 was reduced. These results reveal competitive interactions between barrel and septal circuits in the establishment of precise intracortical circuits.

Item Type:	Paper
Uncontrolled Keywords:	Afferent Pathways/physiology Animals Brain Mapping Glutamates/pharmacology/radiation effects In Vitro Lasers Nerve Net/cytology/ physiology Neuronal Plasticity/drug effects/ physiology Neurons/cytology/drug effects/ physiology Patch-Clamp Techniques Photic Stimulation/instrumentation/methods Rats Rats, Wistar Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Sensory Deprivation/physiology Somatosensory Cortex/ anatomy & histology/drug effects/ physiology Ultraviolet Rays Vibrissae/innervation/physiology
Subjects:	organs, tissues, organelles, cell types and functions > tissues types and functions > barrel cortex organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > neural plasticity organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:	Pologruto, Thomas A. Shepherd, Gordon M. G. Svoboda, Karel
Communities:	CSHL labs > Svoboda lab
Depositing User:	Matt Covey
Date:	24 April 2003
Date Deposited:	26 Jun 2013 19:38
Last Modified:	26 Jun 2013 19:38
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/27919

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