Wolwer, W., Brinkmeyer, J., Riesbeck, M., Freimuller, L., Klimke, A., Wagner, M., Moller, H. J., Klingberg, S., Gaebel, W. (November 2008) Neuropsychological impairments predict the clinical course in schizophrenia. Eur Arch Psychiatry Clin Neurosci, 258 Su. pp. 28-34. ISSN 0940-1334 (Print)0940-1334 (Linking)
Abstract
To add to the open question whether cognitive impairments predict clinical outcome in schizophrenia, a sample of 125 first episode patients was assessed at the onset and over one year of controlled long-term treatment within a study of the German Research Network on Schizophrenia. No relapse according to predefined criteria occurred within the first year, but a total of 29 patients fulfilled post-hoc criteria of "clinical deterioration". Impairments in cognitive functioning assessed by the Trail-Making Test B at the onset of long-term treatment differentiated between patients with vs. without later clinical deterioration and proved to be a significant predictor of the clinical course in a regression analysis outperforming initial clinical status as predictor. However, low sensitivity (72%) and specificity (51%) limit possibilities of a transfer to individual predictions. As a linear combination of neuropsychological and psychopathological variables obtained highest predictive validity, such a combination may improve the prediction of the course of schizophrenic disorders and may ultimately lead to a more efficient and comprehensive treatment planning.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Adult Antipsychotic Agents/therapeutic use Case-Control Studies Cognition Disorders/ diagnosis/ etiology Double-Blind Method Female Haloperidol/therapeutic use Humans Logistic Models Longitudinal Studies Male Neuropsychological Tests Predictive Value of Tests ROC Curve Schizophrenia/ complications Young Adult |
| Subjects: | diseases & disorders diseases & disorders > mental disorders diseases & disorders > mental disorders > schizophrenia |
| CSHL Authors: | |
| Communities: | CSHL labs > Henn lab |
| Depositing User: | Matt Covey |
| Date: | November 2008 |
| Date Deposited: | 26 Feb 2013 15:11 |
| Last Modified: | 26 Feb 2013 15:11 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/27584 |
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