Thornberry, N. A., Lazebnik, Y. (1998) Caspases: enemies within. Science, 281 (5381). pp. 1312-1316. ISSN 0036-8075
Abstract
Apoptosis, an evolutionarily conserved form of cell suicide, requires specialized machinery. The central component of this machinery is a proteolytic system involving a family of proteases called caspases. These enzymes participate in a cascade that is triggered in response to proapoptotic signals and culminates in cleavage of a set of proteins, resulting in disassembly of the cell. Understanding caspase regulation is intimately linked to the ability to rationally manipulate apoptosis for therapeutic gain.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals Apoptosis Catalysis Cysteine Endopeptidases Cysteine Proteinase Inhibitors Drug Therapy Enzyme Activation Enzyme Precursors Humans Neoplasms Substrate Specificity |
| Subjects: | organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > apoptosis organs, tissues, organelles, cell types and functions > cell types and functions > cell functions organs, tissues, organelles, cell types and functions > cell types and functions |
| CSHL Authors: | |
| Communities: | CSHL labs > Labeznik lab |
| Depositing User: | Matt Covey |
| Date: | 1998 |
| Date Deposited: | 12 Dec 2012 17:30 |
| Last Modified: | 12 Dec 2012 17:30 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/26397 |
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