Peptide signaling in Staphylococcus aureus and other Gram-positive bacteria

Lyon, Gholson J., Novick, Richard P. (2004) Peptide signaling in Staphylococcus aureus and other Gram-positive bacteria. Peptides, 25 (9). pp. 1389-1403. ISSN 0196-9781

DOI: 10.1016/j.peptides.2003.11.026


There are two basic types of bacterial communication systems--those in which the signal is directed solely at other organisms and those in which the signal is sensed by the producing organism as well. The former are involved primarily in conjugation; the latter in adaptation to the environment. Gram-positive bacteria use small peptides for both types of signaling, whereas Gram-negative bacteria use homoserine lactones. Since adaptation signals are autoinducers the response is population-density-dependent and has been referred to as "quorum-sensing". Gram-negative bacteria internalize the signals which act upon an intracellular receptor, whereas Gram-positive bacteria use them as ligands for the extracellular receptor of a two-component signaling module. In both cases, the signal activates a complex adaptation response involving many genes.

Item Type: Paper
Uncontrolled Keywords: Amino Acid Sequence Bacterial Physiological Phenomena Bacterial Proteins Bacteriocins Cell Communication Ligands Models, Biological Models, Chemical Molecular Sequence Data Peptides Protein Binding Protein Kinases Sequence Homology, Amino Acid Signal Transduction Staphylococcus aureus Trans-Activators
Subjects: organism description > bacteria
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell signaling
CSHL Authors:
Communities: CSHL labs > Lyon lab
Depositing User: Matt Covey
Date: 2004
Date Deposited: 10 Dec 2012 20:11
Last Modified: 10 Dec 2012 21:25

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