LED arrays as cost effective and efficient light sources for widefield microscopy

Albeanu, D. F., Soucy, E., Sato, T. F., Meister, M., Murthy, V. N. (2008) LED arrays as cost effective and efficient light sources for widefield microscopy. PLoS ONE, 3 (5). ISSN 19326203 (ISSN)

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URL: http://www.ncbi.nlm.nih.gov/pubmed/18478056
DOI: 10.1371/journal.pone.0002146


New developments in fluorophores as well as in detection methods have fueled the rapid growth of optical imaging in the life sciences. Commercial widefield microscopes generally use arc lamps, excitation/ emission filters and shutters for fluorescence imaging. These components can be expensive, difficult to maintain and preclude stable illumination. Here, we describe methods to construct inexpensive and easy-to-use light sources for optical microscopy using light-emitting diodes (LEDs). We also provide examples of its applicability to biological fluorescence imaging. © 2008 Albeanu et al.

Item Type: Paper
Uncontrolled Keywords: article biomedicine cost effectiveness analysis fluorescence analysis illumination image analysis imaging system light light emitting diode microscopy power supply cost benefit analysis economics instrumentation Cost Benefit Analysis
Subjects: Investigative techniques and equipment
Investigative techniques and equipment > optical devices
Investigative techniques and equipment > microscopy > immunoflourescence microscopy
Investigative techniques and equipment > microscopy
CSHL Authors:
Communities: CSHL labs > Albeanu lab
Depositing User: CSHL Librarian
Date: 2008
Date Deposited: 19 Mar 2012 20:56
Last Modified: 04 Dec 2014 16:45
PMCID: PMC2361193
Related URLs:
URI: https://repository.cshl.edu/id/eprint/25444

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