Mechanisms and control of cellular DNA replication

Stillman, B. (1992) Mechanisms and control of cellular DNA replication. In: DNA replication and the cell cycle. Colloquium der Gesellschaft für Biologische Chemie, 43 . Springer-Verlag, Berlin, pp. 127-143. ISBN 978-3-642-77042-5

DOI: 10.1007/978-3-642-77040-1_10


Our understanding of DNA replication in bacteria has relied heavily upon studies on the replication of bacteriophage and plasmid chromosomes and the ability to compare and contrast the mechanisms of DNA synthesis and the functions of the replicative enzymes. In much the same way, studies of the mammalian DNA viruses have contributed to an understanding of the enzymology of cellular DNA replication. The choice model system to date for understanding the enzymology of eukaryotic DNA replication has been the study of Simian Virus 40 (SV40) DNA replication. This is due to the fact that SV40 DNA exists in the cell as a small, circular chromosome that can be thought of as the equivalent of a single replicon within the larger cellular chromosomes. Furthermore, SV40 DNA exists in a chromatin structure that resembles the structure of cellular chromatin and therefore could be a useful model for chromosome, as well as DNA replication (Stillman 1986; DePamphilis and Bradley 1986; Cheng and Kelly 1989; Smith and Stillman 1989).

Item Type: Book Section
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > DNA replication
CSHL Authors:
Communities: CSHL labs > Stillman lab
Highlight: Stillman, Bruce W.
Depositing User: CSHL Librarian
Date: 1992
Date Deposited: 29 Feb 2012 15:25
Last Modified: 20 Jun 2017 14:54

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