Olson, A., Sheth, N., Lee, J. S., Hannon, G. J., Sachidanandam, R. (January 2006) RNAi Codex: a portal/database for short-hairpin RNA (shRNA) gene-silencing constructs. Nucleic Acids Res, 34 (Databa). D153-7. ISSN 1362-4962 (Electronic)
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Abstract
Use of RNA interference (RNAi) in forward genetic screens is proliferating. Currently, short-interfering RNAs (siRNAs) and short-hairpin RNAs (shRNAs) are being used to silence genes to tease out functional information. It is becoming easier to harness RNAi to silence specific genes, owing to the development of libraries of readymade shRNA and siRNA gene-silencing constructs by using a variety of sources. RNAi Codex, which consists of a database of shRNA related information and an associated website, has been developed as a portal for publicly available shRNA resources and is accessible at http://codex.cshl.org. RNAi Codex currently holds data from the Hannon-Elledge shRNA library and allows the use of biologist-friendly gene names to access information on shRNA constructs that can silence the gene of interest. It is designed to hold user-contributed annotations and publications for each construct, as and when such data become available. We will describe features of RNAi Codex and explain the use of the tool.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals Databases Nucleic Acid Humans Internet Mice RNA Interference RNA, Small Interfering chemistry Rats User-Computer Interface |
| Subjects: | bioinformatics > genomics and proteomics > databases > database construction bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNAi bioinformatics > genomics and proteomics > databases > databases bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > shRNA bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > siRNA |
| CSHL Authors: | |
| Communities: | CSHL labs > Hannon lab |
| Depositing User: | CSHL Librarian |
| Date: | 1 January 2006 |
| Date Deposited: | 09 Dec 2011 17:56 |
| Last Modified: | 08 Nov 2017 15:31 |
| PMCID: | PMC1347414 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/22874 |
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