Identification of a nematode chemosensory gene family

Chen, N., Pai, S., Zhao, Z., Mah, A., Newbury, R., Johnsen, R. C., Altun, Z., Moerman, D. G., Baillie, D. L., Stein, L. D. (January 2005) Identification of a nematode chemosensory gene family. Proc Natl Acad Sci U S A, 102 (1). pp. 146-51. ISSN 0027-8424 (Print)

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DOI: 10.1073/pnas.0408307102


Taking advantage of the recent availability of the whole genome sequence of Caenorhabditis briggsae, a closely related nematode to Caenorhabditis elegans, we have examined the chemosensory gene superfamily by using comparative genomic methods. We have identified a chemosensory gene family, serpentine receptor class ab (srab), which exists in both species with 25 members in C. elegans and 14 members in C. briggsae. More than 20% of these gene models are reannotated. The srab family is similar to, but distinct from, the previously described serpentine receptor class a (sra) family and shows a differential expansion in C. elegans similar to that previously described for sra. The cellular expression patterns for multiple members of the srab family in both phasmid neurons in the tail and amphid neurons in the head supports the conclusion that they are chemosensory genes and suggests that they may play a role in integrating chemosensory inputs from both ends of the organism. The expansion of both the srab and sra gene families in C. elegans relative to C. briggsae is due to multiple rounds of tandem duplication and translocation of individual genes.

Item Type: Paper
Uncontrolled Keywords: Animals Caenorhabditis elegans genetics metabolism Caenorhabditis elegans Proteins genetics Chemoreceptors metabolism Chromosome Mapping Evolution Molecular Genes Reporter Models Genetic Multigene Family Phylogeny Promoter Regions (Genetics)
Subjects: bioinformatics > genomics and proteomics > databases > databases
CSHL Authors:
Communities: CSHL labs > Stein lab
School of Biological Sciences > Publications
Depositing User: CSHL Librarian
Date: 4 January 2005
Date Deposited: 13 Jan 2012 19:58
Last Modified: 09 Nov 2017 16:59
PMCID: PMC539308
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