Interneurons of the neocortical inhibitory system

Markram, H., Toledo-Rodriguez, M., Wang, Y., Gupta, A., Silberberg, G., Wu, C. Z. (October 2004) Interneurons of the neocortical inhibitory system. Nature Reviews Neuroscience, 5 (10). pp. 793-807. ISSN 1471-0048

URL: http://www.nature.com/nrn/journal/v5/n10/full/nrn1...
DOI: 10.1038/nrn1519

Abstract

Mammals adapt to a rapidly changing world because of the sophisticated cognitive functions that are supported by the neocortex. The neocortex, which forms almost 80% of the human brain, seems to have arisen from repeated duplication of a stereotypical microcircuit template with subtle specializations for different brain regions and species. The quest to unravel the blueprint of this template started more than a century ago and has revealed an immensely intricate design. The largest obstacle is the daunting variety of inhibitory interneurons that are found in the circuit. This review focuses on the organizing principles that govern the diversity of inhibitory interneurons and their circuits.

Item Type: Paper
Uncontrolled Keywords: CAT VISUAL-CORTEX cat visual cortex RAT FRONTAL-CORTEX rat frontal cortex DUAL INTRACELLULAR-RECORDINGS dual intracellular recordings EXCITATORY POSTSYNAPTIC POTENTIALS excitatory postsynaptic potentials GLUTAMATE-RECEPTOR CHANNELS glutamate receptor channels GOLGI-ELECTRON MICROSCOPE golgi-electron microscope GABAERGIC CELL SUBTYPES GABAergic cell subtypes SYNAPTIC RELEASE synaptic release SITES sites MONKEY CEREBRAL-CORTEX monkey cerebral cortex SINGLE PYRAMIDAL CELLS single pyramidal cells
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neocortical interneurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neocortical interneurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neocortical interneurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neocortical interneurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neocortical interneurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neocortical interneurons
CSHL Authors:
Depositing User: CSHL Librarian
Date: October 2004
Date Deposited: 01 Feb 2012 15:21
Last Modified: 01 Feb 2012 15:21
URI: https://repository.cshl.edu/id/eprint/22433

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