He, L., Hannon, G. J. (August 2004) MicroRNAs: Small RNAs with a big role in gene regulation. Nature Reviews Genetics, 5 (8). pp. 522-532. ISSN 1471-0056
Abstract
MicroRNAs are a family of small, non-coding RNAs that regulate gene expression in a sequence-specific manner. The two founding members of the microRNA family were originally identified in Caenorhabditis elegans as genes that were required for the timed regulation of developmental events. Since then, hundreds of microRNAs have been identified in almost all metazoan genomes, including worms, flies, plants and mammals. MicroRNAs have diverse expression patterns and might regulate various developmental and physiological processes. Their discovery adds a new dimension to our understanding of complex gene regulatory networks.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | DOUBLE-STRANDED-RNA double stranded RNA C-ELEGANS C-Elegans CAENORHABDITIS-ELEGANS Caenorhabditis Elegans MESSENGER-RNA messenger RNA DEVELOPMENTAL SWITCH developmental switch EFFECTOR COMPLEXES effector complexes PAZ DOMAIN PAZ Domain INTERFERENCE interference ARABIDOPSIS Arabidopsis DROSOPHILA Drosophila |
| Subjects: | bioinformatics > genomics and proteomics > annotation > map annotation bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > miRNA bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > miRNA bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > mRNA dynamics |
| CSHL Authors: | |
| Communities: | CSHL labs > Hannon lab |
| Depositing User: | CSHL Librarian |
| Date: | August 2004 |
| Date Deposited: | 01 Feb 2012 18:23 |
| Last Modified: | 02 Dec 2016 15:57 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/22384 |
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