Relation of koniocellular layers of dorsal lateral geniculate to inferior pulvinar nuclei in common marmosets

Huo, B. X., Zeater, N., Lin, M. K., Takahashi, Y. S., Hanada, M., Nagashima, J., Lee, B. C., Hata, J., Zaheer, A., Grunert, U., Miller, M. I., Rosa, M. G. P., Okano, H., Martin, P. R., Mitra, P. P. (July 2019) Relation of koniocellular layers of dorsal lateral geniculate to inferior pulvinar nuclei in common marmosets. Eur J Neurosci. ISSN 0953-816x (Public Dataset)

URL: https://www.ncbi.nlm.nih.gov/pubmed/31344282
DOI: 10.1111/ejn.14529

Abstract

Traditionally, the dorsal lateral geniculate nucleus (LGN) and the inferior pulvinar (IPul) nucleus are considered as anatomically and functionally distinct thalamic nuclei. However, in several primate species it has also been established that the koniocellular (K) layers of LGN and parts of the IPul have a shared pattern of immunoreactivity for the calcium-binding protein calbindin. These calbindin-rich cells constitute a thalamic matrix system which is implicated in thalamocortical synchronization. Further, the K layers and IPul are both involved in visual processing and have similar connections with retina and superior colliculus. Here we confirmed the continuity between calbindin-rich cells in LGN K layers and the central lateral division of IPul (IPulCL) in marmoset monkeys. By employing a high-throughput neuronal tracing method, we found that both the K layers and IPulCL form comparable patterns of connections with striate and extrastriate cortices; these connections are largely different to those of the parvocellular and magnocellular laminae of LGN. Retrograde tracer-labeled cells and anterograde tracer-labeled axon terminals merged seamlessly from IPulCL into LGN K layers. These results support continuity between LGN K layers and IPulCL, providing an anatomical basis for functional congruity of this region of the dorsal thalamic matrix, and calling into question the traditional segregation between LGN and the inferior pulvinar nucleus. This article is protected by copyright. All rights reserved.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > tissues types and functions > dorsal lateral geniculate nucleus
organs, tissues, organelles, cell types and functions > tissues types and functions > thalamus
organs, tissues, organelles, cell types and functions > tissues types and functions > visual cortex
CSHL Authors:
Communities: CSHL labs > Mitra lab
Depositing User: Matthew Dunn
Date: 25 July 2019
Date Deposited: 12 Aug 2019 16:14
Last Modified: 20 Aug 2019 15:12
Related URLs:
Dataset ID:
  • http://marmoset.brainarchitecture.org/
URI: http://repository.cshl.edu/id/eprint/38202

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving