Brain-wide Maps Reveal Stereotyped Cell-Type-Based Cortical Architecture and Subcortical Sexual Dimorphism

Kim, Yongsoo, Yang, Guangyu Robert, Pradhan, Kith, Venkataraju, Kannan Umadevi, Bota, Mihail, García del Molino, Luis Carlos, Fitzgerald, Greg, Ram, Keerthi, He, Miao, Levine, Jesse Maurica, Mitra, Partha, Huang, Z. Josh, Wang, Xiao-Jing, Osten, Pavel (2017) Brain-wide Maps Reveal Stereotyped Cell-Type-Based Cortical Architecture and Subcortical Sexual Dimorphism. Cell, 171 (2). 456-469.e22. ISSN 0092-8674

URL: https://www.ncbi.nlm.nih.gov/pubmed/28985566
DOI: 10.1016/j.cell.2017.09.020

Abstract

The stereotyped features of neuronal circuits are those most likely to explain the remarkable capacity of the brain to process information and govern behaviors, yet it has not been possible to comprehensively quantify neuronal distributions across animals or genders due to the size and complexity of the mammalian brain. Here we apply our quantitative brain-wide (qBrain) mapping platform to document the stereotyped distributions of mainly inhibitory cell types. We discover an unexpected cortical organizing principle: sensory-motor areas are dominated by output-modulating parvalbumin-positive interneurons, whereas association, including frontal, areas are dominated by input-modulating somatostatin-positive interneurons. Furthermore, we identify local cell type distributions with more cells in the female brain in 10 out of 11 sexually dimorphic subcortical areas, in contrast to the overall larger brains in males. The qBrain resource can be further mined to link stereotyped aspects of neuronal distributions to known and unknown functions of diverse brain regions.

Item Type: Paper
Subjects: Investigative techniques and equipment > brain atlas
organs, tissues, organelles, cell types and functions > tissues types and functions > cerebral cortex
CSHL Authors:
Communities: CSHL labs > Huang lab
CSHL labs > Mitra lab
CSHL labs > Osten lab
Depositing User: Matt Covey
Date Deposited: 06 Oct 2017 14:52
Last Modified: 25 Oct 2017 16:19
Related URLs:
URI: http://repository.cshl.edu/id/eprint/35561

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