Unravelling biology and shifting paradigms in cancer with single-cell sequencing

Baslan, T., Hicks, J. (August 2017) Unravelling biology and shifting paradigms in cancer with single-cell sequencing. Nat Rev Cancer, 17 (9). pp. 557-569. ISSN 1474-175x

URL: https://www.ncbi.nlm.nih.gov/pubmed/28835719
DOI: 10.1038/nrc.2017.58

Abstract

The fundamental operative unit of a cancer is the genetically and epigenetically innovative single cell. Whether proliferating or quiescent, in the primary tumour mass or disseminated elsewhere, single cells govern the parameters that dictate all facets of the biology of cancer. Thus, single-cell analyses provide the ultimate level of resolution in our quest for a fundamental understanding of this disease. Historically, this quest has been hampered by technological shortcomings. In this Opinion article, we argue that the rapidly evolving field of single-cell sequencing has unshackled the cancer research community of these shortcomings. From furthering an elemental understanding of intra-tumoural genetic heterogeneity and cancer genome evolution to illuminating the governing principles of disease relapse and metastasis, we posit that single-cell sequencing promises to unravel the biology of all facets of this disease.

Item Type: Paper
Subjects: diseases & disorders > cancer
Investigative techniques and equipment > assays > Single cell sequencing
CSHL Authors:
Communities: CSHL labs > Hicks lab
Depositing User: Matt Covey
Date: 24 August 2017
Date Deposited: 31 Aug 2017 15:33
Last Modified: 31 Aug 2017 15:33
Related URLs:
URI: http://repository.cshl.edu/id/eprint/35260

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