Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

Whyte, P., Buchkovich, K. J., Horowitz, J. M., Friend, S. H., Raybuck, M., Weinberg, R. A., Harlow, E. (July 1988) Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product. Nature, 334 (6178). pp. 124-9. ISSN 0028-0836

URL: http://www.ncbi.nlm.nih.gov/pubmed/2968522
DOI: 10.1038/334124a0

Abstract

One of the cellular targets implicated in the process of transformation by the adenovirus E1A proteins is a 105K cellular protein. Previously, this protein had been shown to form stable protein/protein complexes with the E1A polypeptides but its identity was unknown. Here, we demonstrate that it is the product of the retinoblastoma gene. The interaction between E1A and the retinoblastoma gene product is the first demonstration of a physical link between an oncogene and an anti-oncogene.

Item Type: Paper
Uncontrolled Keywords: Adenovirus Early Proteins Antibodies, Monoclonal/immunology *Cell Division Genes, Structural Humans Molecular Weight Nuclear Proteins/*physiology Oncogene Proteins, Viral/*physiology *Oncogenes Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Retinoblastoma/*genetics
Subjects: organism description > virus > adenovirus
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > oncogene
diseases & disorders > cancer > cancer types > retinoblastoma
CSHL Authors:
Communities: CSHL labs
Depositing User: Gail Sherman
Date: 14 July 1988
Date Deposited: 05 Sep 2017 15:28
Last Modified: 05 Sep 2017 15:28
Related URLs:
URI: http://repository.cshl.edu/id/eprint/35227

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