Supercoiling and Transcription or Vice Versa

Futcher, B. (1988) Supercoiling and Transcription or Vice Versa. Trends in Genetics, 4 (10). pp. 271-272. ISSN 0168-9525

URL: http://www.ncbi.nlm.nih.gov/pubmed/2855556
DOI: 10.1016/0168-9525(88)90166-7

Abstract

DNA extracted appropriately from either prokaryotes or euharyotes is negatively supercoiled. Unconstrained negative supercoils carry free energy that can help unwind the double bel~, separating single strands. Therefore, processes requiring strand sep~tion should occur more easily on negatively supercooled than on relaxed DNA. In particular, initiation of transcription requires RNA polymerase to separate 12-14bp of DNA, and supercoiling would assist this separation 1. Is this free energy of superco'fling

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > analysis and processing > DNA RNA Processing
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transcription
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > RNA polymerase
CSHL Authors:
Communities: CSHL labs > Futcher lab
Depositing User: Gail Sherman
Date Deposited: 06 Oct 2017 15:15
Last Modified: 06 Oct 2017 15:15
Related URLs:
URI: http://repository.cshl.edu/id/eprint/35151

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