Futcher, B. (October 1988) Supercoiling and Transcription or Vice Versa. Trends in Genetics, 4 (10). pp. 271-272. ISSN 0168-9525
Abstract
DNA extracted appropriately from either prokaryotes or euharyotes is negatively supercoiled. Unconstrained negative supercoils carry free energy that can help unwind the double bel~, separating single strands. Therefore, processes requiring strand sep~tion should occur more easily on negatively supercooled than on relaxed DNA. In particular, initiation of transcription requires RNA polymerase to separate 12-14bp of DNA, and supercoiling would assist this separation 1. Is this free energy of superco'fling
| Item Type: | Paper |
|---|---|
| Subjects: | bioinformatics > genomics and proteomics > analysis and processing > DNA RNA Processing bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transcription bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > RNA polymerase |
| CSHL Authors: | |
| Communities: | CSHL labs > Futcher lab |
| Depositing User: | Gail Sherman |
| Date: | October 1988 |
| Date Deposited: | 06 Oct 2017 15:15 |
| Last Modified: | 06 Oct 2017 15:15 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/35151 |
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