Cell-Heritable Stages of Tumor Progression in Transgenic Mice Harboring the Bovine Papillomavirus Type-1 Genome

Sippolathiele, M., Hanahan, D., Howley, P. M. (March 1989) Cell-Heritable Stages of Tumor Progression in Transgenic Mice Harboring the Bovine Papillomavirus Type-1 Genome. Molecular and Cellular Biology, 9 (3). pp. 925-934. ISSN 0270-7306

URL: http://www.ncbi.nlm.nih.gov/pubmed/2542769
DOI: 10.1128/MCB.9.3.925

Abstract

Tumorigenesis of dermal fibroblasts in a line of transgenic mice carrying the BPV-1 genome was found to involve distinct proliferative stages. Cell cultures derived from normal skin, from benign proliferative fibromatoses, and from malignant fibrosarcomas each evidenced distinguishable, cell-heritable characteristics. The latent viral genome was transcriptionally inactive in normal-appearing skin and was activated in the dermal fibromatoses. Fibrosarcoma cells grew continuously in culture, formed domelike foci, and had a more rounded, anaplastic appearance. Independent cultures derived from the fibromatoses varied in their proliferative characteristics, which correlated well with the levels of viral gene expression. In contrast, progression to malignancy was not accompanied by a further increase in transgene activity, which strongly implicated cellular genetic changes in the later stages of tumorigenesis.

Item Type: Paper
Subjects: organism description > animal > mammal > rodent > mouse
organism description > virus > papillomavirus
CSHL Authors:
Communities: CSHL labs
Depositing User: Gail Sherman
Date: March 1989
Date Deposited: 23 Jun 2017 18:59
Last Modified: 23 Jun 2017 18:59
PMCID: PMC362681
Related URLs:
URI: http://repository.cshl.edu/id/eprint/34906

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