Quinlan, M. P. (August 1989) The Ad5 12S growth factor induces F9 cell proliferation and differentiation. Oncogene, 4 (8). pp. 1051-5. ISSN 0950-9232
Abstract
The 12S gene of the E1A region of adenovirus induces the production of a growth factor that is necessary for the immortalization of primary epithelial cells. This growth factor is able to replace the strict serum requirement of F9 cells, a teratocarcinoma-derived embryonal carcinoma cell line. Furthermore, the growth factor induces a morphological alteration in the F9 cells such that they resemble visceral endoderm cells and express the surface antigens, SSEA-1 and SSEA-3, characteristic of these differentiated cells.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Adenoviruses, Human/*physiology Animals Antigens, CD15 Antigens, Surface/analysis Cell Differentiation Cell Division Fluorescent Antibody Technique Glycolipids/analysis Growth Substances/genetics/*pharmacology In Vitro Mice Teratoma/*pathology Tumor Cells, Cultured |
| Subjects: | organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell differentiation organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell proliferation |
| CSHL Authors: | |
| Communities: | CSHL labs |
| Depositing User: | Gail Sherman |
| Date: | August 1989 |
| Date Deposited: | 26 Jun 2017 19:30 |
| Last Modified: | 26 Jun 2017 19:30 |
| URI: | https://repository.cshl.edu/id/eprint/34895 |
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