Regulation of Meiosis - from DNA-Binding Protein to Protein-Kinase

McLeod, M. (July 1989) Regulation of Meiosis - from DNA-Binding Protein to Protein-Kinase. Bioessays, 11 (1). pp. 9-14. ISSN 0265-9247

URL: http://www.ncbi.nlm.nih.gov/pubmed/2673232
DOI: 10.1002/bies.950110104

Abstract

The transition from mitotic cell division to meiosis in yeast is governed by both the mating-type genes and signals from the environment. Analysis of mutants that are unable to regulate entry into meiosis has identified many genes that function in this process and in some cases, the biochemical activity of their protein products has been described. At least two of the the mating-type genes of Saccharomyces cerevisiae encode DNA binding proteins that regulate transcription of unlinked genes required for entry into meiosis. Meiotic development of the distantly related yeast, Schizosaccharomyces pombe, is also controlled by the mating-type genes but in this yeast, their role is to regulate expression of a protein that acts as an inhibitor of a protein kinase. The ability to use the powerful tool of genetics in yeast has provided us with many new insights into the problem of meiotic development.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > DNA binding protein
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > kinase
organs, tissues, organelles, cell types and functions > organelles, types and functions > meiosis
CSHL Authors:
Communities: CSHL labs
Depositing User: Gail Sherman
Date: July 1989
Date Deposited: 27 Jun 2017 18:21
Last Modified: 27 Jun 2017 18:21
Related URLs:
URI: http://repository.cshl.edu/id/eprint/34878

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