Cerebellar granule cells acquire a widespread predictive feedback signal during motor learning

Giovannucci, A., Badura, A., Deverett, B., Najafi, F., Pereira, T. D., Gao, Z. Y., Ozden, I., Kloth, A. D., Pnevmatikakis, E., Paninski, L., De Zeeuw, C. I., Medina, J. F., Wang, S. S. H. (May 2017) Cerebellar granule cells acquire a widespread predictive feedback signal during motor learning. Nature Neuroscience, 20 (5). pp. 727-734. ISSN 1097-6256

URL: https://www.ncbi.nlm.nih.gov/pubmed/28319608
DOI: 10.1038/nn.4531

Abstract

Cerebellar granule cells, which constitute half the brain's neurons, supply Purkinje cells with contextual information necessary for motor learning, but how they encode this information is unknown. Here we show, using two-photon microscopy to track neural activity over multiple days of cerebellum-dependent eyeblink conditioning in mice, that granule cell populations acquire a dense representation of the anticipatory eyelid movement. Initially, granule cells responded to neutral visual and somatosensory stimuli as well as periorbital airpuffs used for training. As learning progressed, two-thirds of monitored granule cells acquired a conditional response whose timing matched or preceded the learned eyelid movements. Granule cell activity covaried trial by trial to form a redundant code. Many granule cells were also active during movements of nearby body structures. Thus, a predictive signal about the upcoming movement is widely available at the input stage of the cerebellar cortex, as required by forward models of cerebellar control.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > tissues types and functions > cerebellum
organism description > animal behavior > learning
organs, tissues, organelles, cell types and functions > tissues types and functions > motor cortex
CSHL Authors:
Communities: CSHL labs > Churchland lab
Depositing User: Matt Covey
Date: May 2017
Date Deposited: 19 May 2017 20:05
Last Modified: 19 May 2017 20:05
Related URLs:
URI: http://repository.cshl.edu/id/eprint/34792

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