Antimicrobial and toxicological studies on an antiseptic based on hexachlorophene and destructive distillate of castor oil

Siddiqui, M. A., Mahmood, I., Basit, N., Ahmed, S., Bukhari, A. Q. (July 1978) Antimicrobial and toxicological studies on an antiseptic based on hexachlorophene and destructive distillate of castor oil. G Batteriol Virol Immunol, 71 (7-12). pp. 181-91. ISSN 0390-5462 (Print)0390-5462 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/549568

Abstract

Bactericidal, bacteriostatic, fungistatic and toxicological evaluaton of an emulsion containing 0.25% hexachlorophene (W/V), 9.5% terpineol (V/V), 1.5% oil of terpentine (V/V), 13% ethanol (V/V), 6% castor oil distillate 1201275 degrees C (V/V) and 6% sodium salt of the residue (W/V) in aqueous medium was performed. The bactericidal concentration for Salmonella typhi was found to be 1:400 which increased to 1:350 in the presence of 5% horse serum. The bacteriostatic concentration of the emulsion varied from organism to organism. A 4% solution of the emulsione was found to be most effective against Microsporum vanbreuseghemii showing an inhibition zone of 7.2 cm and was least effective on Aspergillus niger. 1 to 8% solution of the emulsion given orally or instilled into conjunctival sacs of albino mice indicated lethal and insignificant toxic manifestations respectively but a dose equivalent to 50 mg/Kg given subcutaneously was found to produce a subacute lethal effect in guinea pigs.

Item Type: Paper
Uncontrolled Keywords: Animals Anti-Infective Agents, Local/*pharmacology/toxicity Bacteria/*drug effects Castor Oil/*pharmacology/toxicity Fungi/*drug effects Hexachlorophene/*pharmacology/toxicity Mice
Subjects: diseases & disorders > Bacterial Infections
diseases & disorders
organism description > bacteria
CSHL Authors:
Communities: CSHL labs
Depositing User: Matt Covey
Date: July 1978
Date Deposited: 25 Aug 2016 15:07
Last Modified: 25 Aug 2016 15:07
URI: http://repository.cshl.edu/id/eprint/33329

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