Siddiqui, M. A., Mahmood, I., Basit, N., Ahmed, S., Bukhari, A. Q. (July 1978) Antimicrobial and toxicological studies on an antiseptic based on hexachlorophene and destructive distillate of castor oil. G Batteriol Virol Immunol, 71 (7-12). pp. 181-91. ISSN 0390-5462 (Print)0390-5462 (Linking)
Abstract
Bactericidal, bacteriostatic, fungistatic and toxicological evaluaton of an emulsion containing 0.25% hexachlorophene (W/V), 9.5% terpineol (V/V), 1.5% oil of terpentine (V/V), 13% ethanol (V/V), 6% castor oil distillate 1201275 degrees C (V/V) and 6% sodium salt of the residue (W/V) in aqueous medium was performed. The bactericidal concentration for Salmonella typhi was found to be 1:400 which increased to 1:350 in the presence of 5% horse serum. The bacteriostatic concentration of the emulsion varied from organism to organism. A 4% solution of the emulsione was found to be most effective against Microsporum vanbreuseghemii showing an inhibition zone of 7.2 cm and was least effective on Aspergillus niger. 1 to 8% solution of the emulsion given orally or instilled into conjunctival sacs of albino mice indicated lethal and insignificant toxic manifestations respectively but a dose equivalent to 50 mg/Kg given subcutaneously was found to produce a subacute lethal effect in guinea pigs.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals Anti-Infective Agents, Local/*pharmacology/toxicity Bacteria/*drug effects Castor Oil/*pharmacology/toxicity Fungi/*drug effects Hexachlorophene/*pharmacology/toxicity Mice |
| Subjects: | diseases & disorders > Bacterial Infections diseases & disorders organism description > bacteria |
| CSHL Authors: | |
| Communities: | CSHL labs |
| Depositing User: | Matt Covey |
| Date: | July 1978 |
| Date Deposited: | 25 Aug 2016 15:07 |
| Last Modified: | 25 Aug 2016 15:07 |
| URI: | https://repository.cshl.edu/id/eprint/33329 |
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