DNA tumor virus transforming proteins and the cell cycle

Moran, E. (February 1993) DNA tumor virus transforming proteins and the cell cycle. Curr Opin Genet Dev, 3 (1). pp. 63-70. ISSN 0959-437X (Print)

URL: http://www.ncbi.nlm.nih.gov/pubmed/8453277
DOI: 10.1016/S0959-437X(05)80342-9

Abstract

Studies using the transforming proteins of the small DNA tumor viruses point to the role of the E2F cellular transcription factor in regulating cell cycle specific gene expression. The evidence derived suggests that E2F is controlled by the retinoblastoma gene product and related proteins, including their associated cyclins. Studies using DNA tumor virus products further suggest the existence of additional pathways of cell-cycle activation.

Item Type: Paper
Uncontrolled Keywords: Amino Acid Sequence Animals Base Sequence Carrier Proteins Cell Cycle Cell Cycle Proteins Cell Transformation, Viral Cyclins/metabolism DNA Tumor Viruses/genetics/ physiology DNA-Binding Proteins E2F Transcription Factors Humans Models, Biological Molecular Sequence Data Oncogene Proteins, Viral/genetics/ physiology Retinoblastoma Protein/physiology Transcription Factor DP1 Transcription Factors/ physiology
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > Cyclins
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell cycle
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > DNA binding protein
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > oncogene
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor
organism description > virus
CSHL Authors:
Communities: CSHL labs
Depositing User: Matt Covey
Date: February 1993
Date Deposited: 19 Apr 2016 18:45
Last Modified: 19 Apr 2016 18:45
Related URLs:
URI: http://repository.cshl.edu/id/eprint/32502

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