Maintenance of T cell function in the face of chronic antigen stimulation and repeated reactivation for a latent virus infection

Mackay, L. K., Wakim, L., van Vliet, C. J., Jones, C. M., Mueller, S. N., Bannard, O., Fearon, D. T., Heath, W. R., Carbone, F. R. (March 2012) Maintenance of T cell function in the face of chronic antigen stimulation and repeated reactivation for a latent virus infection. J Immunol, 188 (5). pp. 2173-8. ISSN 0022-1767

URL: http://www.ncbi.nlm.nih.gov/pubmed/22271651
DOI: 10.4049/jimmunol.1102719

Abstract

Persisting infections are often associated with chronic T cell activation. For certain pathogens, this can lead to T cell exhaustion and survival of what is otherwise a cleared infection. In contrast, for herpesviruses, T cells never eliminate infection once it is established. Instead, effective immunity appears to maintain these pathogens in a state of latency. We used infection with HSV to examine whether effector-type T cells undergoing chronic stimulation retained functional and proliferative capacity during latency and subsequent reactivation. We found that latency-associated T cells exhibited a polyfunctional phenotype and could secrete a range of effector cytokines. These T cells were also capable of mounting a recall proliferative response on HSV reactivation and could do so repeatedly. Thus, for this latent infection, T cells subjected to chronic Ag stimulation and periodic reactivation retain the ability to respond to local virus challenge.

Item Type: Paper
Uncontrolled Keywords: Adoptive Transfer Animals CD8-Positive T-Lymphocytes/*immunology/transplantation/virology Chronic Disease Epitopes, T-Lymphocyte/administration & dosage/immunology/*toxicity Ganglia, Sensory/enzymology/immunology/pathology Granzymes/biosynthesis Herpes Simplex/*immunology/pathology/*virology Herpesvirus 1, Human/*immunology/pathogenicity Mice Mice, Inbred C57BL Mice, Transgenic Viral Envelope Proteins/administration & dosage/*toxicity Virus Activation/*immunology Virus Latency/*immunology
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells

organism description > virus
CSHL Authors:
Communities: CSHL Cancer Center Program > Signal Transduction
CSHL labs > Fearon lab
Depositing User: Matt Covey
Date: 1 March 2012
Date Deposited: 16 Oct 2015 14:20
Last Modified: 16 Oct 2015 14:20
PMCID: PMC3378511
Related URLs:
URI: http://repository.cshl.edu/id/eprint/31929

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