Mackay, L. K., Wakim, L., van Vliet, C. J., Jones, C. M., Mueller, S. N., Bannard, O., Fearon, D. T., Heath, W. R., Carbone, F. R. (March 2012) Maintenance of T cell function in the face of chronic antigen stimulation and repeated reactivation for a latent virus infection. J Immunol, 188 (5). pp. 2173-8. ISSN 0022-1767
Abstract
Persisting infections are often associated with chronic T cell activation. For certain pathogens, this can lead to T cell exhaustion and survival of what is otherwise a cleared infection. In contrast, for herpesviruses, T cells never eliminate infection once it is established. Instead, effective immunity appears to maintain these pathogens in a state of latency. We used infection with HSV to examine whether effector-type T cells undergoing chronic stimulation retained functional and proliferative capacity during latency and subsequent reactivation. We found that latency-associated T cells exhibited a polyfunctional phenotype and could secrete a range of effector cytokines. These T cells were also capable of mounting a recall proliferative response on HSV reactivation and could do so repeatedly. Thus, for this latent infection, T cells subjected to chronic Ag stimulation and periodic reactivation retain the ability to respond to local virus challenge.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Adoptive Transfer Animals CD8-Positive T-Lymphocytes/*immunology/transplantation/virology Chronic Disease Epitopes, T-Lymphocyte/administration & dosage/immunology/*toxicity Ganglia, Sensory/enzymology/immunology/pathology Granzymes/biosynthesis Herpes Simplex/*immunology/pathology/*virology Herpesvirus 1, Human/*immunology/pathogenicity Mice Mice, Inbred C57BL Mice, Transgenic Viral Envelope Proteins/administration & dosage/*toxicity Virus Activation/*immunology Virus Latency/*immunology |
| Subjects: | organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells organism description > virus |
| CSHL Authors: | |
| Communities: | CSHL Cancer Center Program > Signal Transduction CSHL labs > Fearon lab |
| Depositing User: | Matt Covey |
| Date: | 1 March 2012 |
| Date Deposited: | 16 Oct 2015 14:20 |
| Last Modified: | 16 Oct 2015 14:20 |
| PMCID: | PMC3378511 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/31929 |
Actions (login required)
 |
Administrator's edit/view item |