A vertebrate actin-related protein is a component of a multisubunit complex involved in microtubule-based vesicle motility

Lees-Miller, J. P., Helfman, D. M., Schroer, T. A. (September 1992) A vertebrate actin-related protein is a component of a multisubunit complex involved in microtubule-based vesicle motility. Nature, 359 (6392). pp. 244-6. ISSN 0028-0836 (Print)0028-0836 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/1528266
DOI: 10.1038/359244a0

Abstract

Actin is a cytoskeletal protein which is highly conserved across eukaryotic phyla. Actin filaments, in association with a family of myosin motor proteins, are required for cellular motile processes as diverse as vesicle transport, cell locomotion and cytokinesis. Many organisms have several closely related actin isoforms. In addition to conventional actins, yeasts contain actin-related proteins that are essential for viability. We show here that vertebrates also contain an actin-related protein (actin-RPV). Actin-RPV is a major component of the dynactin complex, an activator of dynein-driven vesicle movement, indicating that unlike conventional actins which work in conjunction with myosin motors, actin-RPV may be involved in cytoplasmic movements via a microtubule-based system.

Item Type: Paper
Uncontrolled Keywords: Actins/*physiology Amino Acid Sequence Animals Base Sequence Biological Transport/physiology Cell Movement/*physiology Electrophoresis, Gel, Two-Dimensional Electrophoresis, Polyacrylamide Gel Isoelectric Point Microtubule Proteins/*physiology Microtubules/*physiology Molecular Sequence Data Oligonucleotide Probes Rats Sequence Homology, Nucleic Acid
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > actin
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell motility
organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > microtubule
CSHL Authors:
Communities: CSHL labs > Helfman lab
Depositing User: Matt Covey
Date: 17 September 1992
Date Deposited: 23 Sep 2015 14:32
Last Modified: 23 Sep 2015 14:32
Related URLs:
URI: http://repository.cshl.edu/id/eprint/31836

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