Input-specific maturation of synaptic dynamics of parvalbumin interneurons in primary visual cortex

Lu, J., Tucciarone, J., Lin, Y., Huang, Z. J. (2014) Input-specific maturation of synaptic dynamics of parvalbumin interneurons in primary visual cortex. Proceedings of the National Academy of Sciences of the United States of America, 111 (47). pp. 16895-16900. ISSN 0027-8424

URL: http://www.ncbi.nlm.nih.gov/pubmed/25385583
DOI: 10.1073/pnas.1400694111

Abstract

Cortical networks consist of local recurrent circuits and long-range pathways from other brain areas. Parvalbumin-positive interneurons (PVNs) regulate the dynamic operation of local ensembles as well as the temporal precision of afferent signals. The synaptic recruitment of PVNs that support these circuit operations is not well-understood. Here we demonstrate that the synaptic dynamics of PVN recruitment in mouse visual cortex are customized according to input source with distinct maturation profiles. Whereas the long-range inputs to PVNs show strong short-term depression throughout postnatal maturation, local inputs from nearby pyramidal neurons progressively lose such depression. This enhanced local recruitment depends on PVN-mediated reciprocal inhibition and results from both pre- and postsynaptic mechanisms, including calcium-permeable AMPA receptors at PVN postsynaptic sites. Although short-term depression of long-range inputs is well-suited for afferent signal detection, the robust dynamics of local inputs may facilitate rapid and proportional PVN recruitment in regulating local circuit operations.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons

organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > synaptic plasticity
organs, tissues, organelles, cell types and functions > tissues types and functions > visual cortex
CSHL Authors:
Communities: CSHL labs > Huang lab
Depositing User: Matt Covey
Date Deposited: 21 Nov 2014 17:05
Last Modified: 17 Dec 2014 14:56
PMCID: PMC4250102
Related URLs:
URI: http://repository.cshl.edu/id/eprint/30925

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