Autoantibodies to Transfer Rna-Related Antigens in Myositis

Bernstein, Robert M., Bunn, Christopher C., Mathews, Michael B. (1985) Autoantibodies to Transfer Rna-Related Antigens in Myositis. In: Protides of the Biological Fluids. Elsevier, pp. 347-350. ISBN 0079-7065

URL: http://www.sciencedirect.com/science/article/pii/B...
DOI: 10.1016/B978-0-08-033215-4.50085-6

Abstract

Abstract Autoantibodies directed at tRNA related antigens are a feature of myositis, particularly in a syndrome of myositis with fibrosing alveolitis. Three antibodies, Jo-1, PL-7 and PL-12, inhibit the aminoacyl-tRNA synthetases for histidine, threonine and alanine, respectively. Jo-1 and PL-7 antibodies recognise a protein antigen (the enzyme) to which tRNA is bound, whereas the PL-12 specificity contains separate antibodies to alanyl-tRNA synthetase and tRNA (Ala). These findings are discussed in relation to the antigen-driven and anti-idiotype hypotheses of autoantibody formation.

Item Type: Book Section
Uncontrolled Keywords: Autoantibody cellular antigen transfer RNA aminoacyl-tRNA synthetase idiotype antiidiotype myositis fibrosing alveolitis interstitial pneumonitis
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNA expression
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > monoclonal antibody
CSHL Authors:
Communities: CSHL labs
Depositing User: Matt Covey
Date: 1985
Date Deposited: 18 Jul 2014 14:50
Last Modified: 18 Jul 2014 14:50
URI: http://repository.cshl.edu/id/eprint/30543

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving