Bernstein, Robert M., Bunn, Christopher C., Mathews, Michael B. (1985) Autoantibodies to Transfer Rna-Related Antigens in Myositis. In: Protides of the Biological Fluids. Elsevier, pp. 347-350. ISBN 0079-7065
Abstract
Abstract Autoantibodies directed at tRNA related antigens are a feature of myositis, particularly in a syndrome of myositis with fibrosing alveolitis. Three antibodies, Jo-1, PL-7 and PL-12, inhibit the aminoacyl-tRNA synthetases for histidine, threonine and alanine, respectively. Jo-1 and PL-7 antibodies recognise a protein antigen (the enzyme) to which tRNA is bound, whereas the PL-12 specificity contains separate antibodies to alanyl-tRNA synthetase and tRNA (Ala). These findings are discussed in relation to the antigen-driven and anti-idiotype hypotheses of autoantibody formation.
| Item Type: | Book Section |
|---|---|
| Uncontrolled Keywords: | Autoantibody cellular antigen transfer RNA aminoacyl-tRNA synthetase idiotype antiidiotype myositis fibrosing alveolitis interstitial pneumonitis |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNA expression bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > monoclonal antibody |
| CSHL Authors: | |
| Communities: | CSHL labs |
| Depositing User: | Matt Covey |
| Date: | 1985 |
| Date Deposited: | 18 Jul 2014 14:50 |
| Last Modified: | 18 Jul 2014 14:50 |
| URI: | https://repository.cshl.edu/id/eprint/30543 |
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