Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP

Freiman, R. N., Herr, W. (December 1997) Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP. Genes and Development, 11 (23). pp. 3122-7. ISSN 08909369 (ISSN)

[img]
Preview
PDF
Herr_GenesDev1997.pdf

Download (791Kb) | Preview
URL: http://www.ncbi.nlm.nih.gov/pubmed/9389645
DOI: 10.1101/gad.11.23.3122

Abstract

Upon infection of human cells, the herpes simplex virus protein VP16 associates with the endogenous cell-proliferation factor HCF. VP16 can also associate with HCFs from invertebrates, suggesting that VP16 mimics a cellular protein whose interaction with HCF has been conserved. Here, we show that VP16 mimics the human basic leucine-zipper protein LZIP, which, through association with HCF, may control cell-cycle progression. VP16 and LZIP share a tetrapeptide motif-D/EHXY-used to associate with human HCF. The LZIP-related Drosophila protein BBF-2/dCREB-A contains this HCF-binding motif, indicating that the LZIP-HCF interaction has been conserved during metazoan evolution.

Item Type: Paper
Uncontrolled Keywords: Amino Acid Sequence Animals Binding Sites Cell Division Cell Line, Transformed Cyclic AMP Response Element-Binding Protein A DNA-Binding Proteins/metabolism Drosophila Proteins Drosophila melanogaster Hela Cells Herpes Simplex Virus Protein Vmw65/ metabolism Herpesvirus 1, Human/ metabolism Host Cell Factor C1 Humans Leucine Zippers Mice Molecular Mimicry Molecular Sequence Data Proteins/genetics/ metabolism Recombinant Fusion Proteins/genetics/metabolism Research Support, U.S. Gov't, P.H.S. Sequence Homology, Amino Acid Transcription Factors
Subjects: organism description > animal > insect > Drosophila
diseases & disorders > viral diseases
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell division
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > cell line
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > cell line
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > cell line

bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > DNA binding protein
organism description > virus > herpes simplex virus
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor
CSHL Authors:
Communities: CSHL labs > Herr lab
Depositing User: Kathleen Darby
Date: 1 December 1997
Date Deposited: 07 May 2014 15:01
Last Modified: 07 May 2014 15:01
PMCID: PMC316754
Related URLs:
URI: http://repository.cshl.edu/id/eprint/30025

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving