Freiman, R. N., Herr, W.
(December 1997)
Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP.
Genes and Development, 11 (23).
pp. 3122-7.
ISSN 08909369 (ISSN)
Abstract
Upon infection of human cells, the herpes simplex virus protein VP16 associates with the endogenous cell-proliferation factor HCF. VP16 can also associate with HCFs from invertebrates, suggesting that VP16 mimics a cellular protein whose interaction with HCF has been conserved. Here, we show that VP16 mimics the human basic leucine-zipper protein LZIP, which, through association with HCF, may control cell-cycle progression. VP16 and LZIP share a tetrapeptide motif-D/EHXY-used to associate with human HCF. The LZIP-related Drosophila protein BBF-2/dCREB-A contains this HCF-binding motif, indicating that the LZIP-HCF interaction has been conserved during metazoan evolution.
| Item Type: |
Paper
|
| Uncontrolled Keywords: |
Amino Acid Sequence
Animals
Binding Sites
Cell Division
Cell Line, Transformed
Cyclic AMP Response Element-Binding Protein A
DNA-Binding Proteins/metabolism
Drosophila Proteins
Drosophila melanogaster
Hela Cells
Herpes Simplex Virus Protein Vmw65/ metabolism
Herpesvirus 1, Human/ metabolism
Host Cell Factor C1
Humans
Leucine Zippers
Mice
Molecular Mimicry
Molecular Sequence Data
Proteins/genetics/ metabolism
Recombinant Fusion Proteins/genetics/metabolism
Research Support, U.S. Gov't, P.H.S.
Sequence Homology, Amino Acid
Transcription Factors |
| Subjects: |
organism description > animal > insect > Drosophila
diseases & disorders > viral diseases
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell division
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > cell line
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > cell line
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > cell line
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > DNA binding protein
organism description > virus > herpes simplex virus
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Herr lab |
| Depositing User: |
Kathleen Darby
|
| Date: |
1 December 1997 |
| Date Deposited: |
07 May 2014 15:01 |
| Last Modified: |
07 May 2014 15:01 |
| PMCID: |
PMC316754 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/30025 |
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