The herpes simplex virus VP16-induced complex: mechanisms of combinatorial transcriptional regulation

Herr, W. (1998) The herpes simplex virus VP16-induced complex: mechanisms of combinatorial transcriptional regulation. Cold Spring Harbor Symposia on Quantitative Biology, 63. pp. 599-607. ISSN 00917451 (ISSN)

URL: http://www.ncbi.nlm.nih.gov/pubmed/10384325
DOI: 10.1101/sqb.1998.63.599

Abstract

At any one time, a cell transcribes only a small subsetof all the genes in its genome. To provide specificity tothe regulation of transcription, each cell relies on the assembly of particular sets or combinations of transcriptionfactors on different promoters. Through such combinatorial mechanisms, individual transcription factors can acquire different activities depending on the presence or absence of other coregulators in the same cell, thus reducingthe total number of regulators needed to control cellulartranscription...

Item Type: Paper
Uncontrolled Keywords: Animals DNA/chemistry/genetics DNA, Viral/chemistry/genetics DNA-Binding Proteins/chemistry/metabolism Gene Expression Regulation, Viral Herpes Simplex Virus Protein Vmw65/ metabolism Host Cell Factor C1 Humans Models, Molecular Nucleic Acid Conformation Octamer Transcription Factor-1 Promoter Regions (Genetics) Protein Structure, Secondary Research Support, U.S. Gov't, P.H.S. Simplexvirus/ genetics Transcription Factors/chemistry/metabolism Transcription, Genetic
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transcription
bioinformatics > genomics and proteomics > design > nucleic acid design
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > DNA binding protein
organism description > virus > herpes simplex virus
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor
CSHL Authors:
Communities: CSHL labs > Herr lab
Depositing User: Kathleen Darby
Date: 1998
Date Deposited: 01 May 2014 18:10
Last Modified: 01 May 2014 18:10
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29895

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving