Broadly tuned and respiration-independent inhibition in the olfactory bulb of awake mice

Cazakoff, B. N., Lau, B. Y., Crump, K. L., Demmer, H. S., Shea, S. D. (March 2014) Broadly tuned and respiration-independent inhibition in the olfactory bulb of awake mice. Nature Neuroscience. ISSN 1097-6256

URL: http://www.ncbi.nlm.nih.gov/pubmed/24584050
DOI: 10.1038/nn.3669

Abstract

Olfactory representations are shaped by brain state and respiration. The interaction and circuit substrates of these influences are unclear. Granule cells (GCs) in the main olfactory bulb (MOB) are presumed to sculpt activity reaching the cortex via inhibition of mitral/tufted cells (MTs). GCs potentially make ensemble activity more sparse by facilitating lateral inhibition among MTs and/or enforce temporally precise activity locked to breathing. Yet the selectivity and temporal structure of wakeful GC activity are unknown. We recorded GCs in the MOB of anesthetized and awake mice and identified state-dependent features of odor coding and temporal patterning. Under anesthesia, GCs were sparsely active and strongly and synchronously coupled to respiration. Upon waking, GCs desynchronized, broadened their tuning and largely fired independently from respiration. Thus, during wakefulness, GCs exhibited stronger odor responses with less temporal structure. We propose that during wakefulness GCs may shape MT odor responses through broadened lateral interactions rather than respiratory synchronization.

Item Type: Paper
Subjects: organism description > animal behavior
organism description > animal > mammal > rodent > mouse
organism description > animal behavior > olfactory
organs, tissues, organelles, cell types and functions > tissues types and functions > olfactory bulb
CSHL Authors:
Communities: CSHL labs > Shea lab
Watson School > Publications
Depositing User: Matt Covey
Date: 2 March 2014
Date Deposited: 07 Mar 2014 16:27
Last Modified: 23 Sep 2014 14:03
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29573

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