Chromosome cohesion, condensation, and separation

Hirano, T. (2000) Chromosome cohesion, condensation, and separation. Annual Review of Biochemistry, 69. pp. 115-144. ISSN 0066-4154

URL: http://www.ncbi.nlm.nih.gov/pubmed/10966455
DOI: 10.1146/annurev.biochem.69.1.115

Abstract

The faithful segregation of genetic information requires highly orchestrated changes of chromosome structure during the mitotic cell cycle. The linkage between duplicated sister DNAs is established during S phase and maintained throughout G2 phase (cohesion). In early mitosis, dramatic structural changes occur to produce metaphase chromosomes, each consisting of a pair of compacted sister chromatids (condensation). At anaphase onset, a signal is produced to disrupt the linkage between sister chromatids (separation), allowing them to be pulled apart to opposite poles of the cell. This review discusses our current understanding of the three stages of large-scale structural changes of chromosomes in eukaryotic cells. Recent genetic and biochemical studies have identified key components involved in these processes and started to uncover hitherto unexpected functional links between mitotic chromosome dynamics and other important chromosome functions.

Item Type: Paper
Uncontrolled Keywords: chromosome dynamics cohesin condensin SMC proteins SISTER-CHROMATID COHESION INNER CENTROMERE PROTEIN DNA TOPOISOMERASE-II CLEAVAGE FURROW FORMATION STRAND-BREAK REPAIR COILED-COIL PROTEIN SACCHAROMYCES-CEREVISIAE FISSION YEAST SCHIZOSACCHAROMYCES-POMBE CELL-CYCLE
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosome
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function > chromosome

bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > cohesin
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > cohesin complex
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > condensin complex
CSHL Authors:
Communities: CSHL labs > Hirano lab
Depositing User: Matt Covey
Date: 2000
Date Deposited: 31 Jan 2014 16:50
Last Modified: 31 Jan 2014 16:50
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29363

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