Hirano, T.
(2000)
Chromosome cohesion, condensation, and separation.
Annual Review of Biochemistry, 69.
pp. 115-144.
ISSN 0066-4154
Abstract
The faithful segregation of genetic information requires highly orchestrated changes of chromosome structure during the mitotic cell cycle. The linkage between duplicated sister DNAs is established during S phase and maintained throughout G2 phase (cohesion). In early mitosis, dramatic structural changes occur to produce metaphase chromosomes, each consisting of a pair of compacted sister chromatids (condensation). At anaphase onset, a signal is produced to disrupt the linkage between sister chromatids (separation), allowing them to be pulled apart to opposite poles of the cell. This review discusses our current understanding of the three stages of large-scale structural changes of chromosomes in eukaryotic cells. Recent genetic and biochemical studies have identified key components involved in these processes and started to uncover hitherto unexpected functional links between mitotic chromosome dynamics and other important chromosome functions.
| Item Type: |
Paper
|
| Uncontrolled Keywords: |
chromosome dynamics
cohesin
condensin
SMC proteins
SISTER-CHROMATID COHESION
INNER CENTROMERE PROTEIN
DNA
TOPOISOMERASE-II
CLEAVAGE FURROW FORMATION
STRAND-BREAK REPAIR
COILED-COIL PROTEIN
SACCHAROMYCES-CEREVISIAE
FISSION YEAST
SCHIZOSACCHAROMYCES-POMBE
CELL-CYCLE |
| Subjects: |
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosome
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function > chromosome
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > cohesin
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > cohesin complex
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > condensin complex |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Hirano lab |
| Depositing User: |
Matt Covey
|
| Date: |
2000 |
| Date Deposited: |
31 Jan 2014 16:50 |
| Last Modified: |
31 Jan 2014 16:50 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/29363 |
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