Small nuclear RNA genes: a model system to study fundamental mechanisms of transcription

Hernandez, N. (July 2001) Small nuclear RNA genes: a model system to study fundamental mechanisms of transcription. Journal of Biological Chemistry, 276 (29). pp. 26733-26736. ISSN 0021-9258

URL: http://www.ncbi.nlm.nih.gov/pubmed/11390411
DOI: 10.1074/jbc.R100032200

Abstract

The human small nuclear RNA (snRNA)1 genes, which encode snRNAs that are involved in RNA processing reactions such as mRNA splicing, serve as prototypes for a family of genes whose promoters are characterized by the presence of a proximal sequence element (PSE) and a distal sequence element (DSE). From a transcription point of view, this family of genes is highly interesting because all of its members have very similar promoters, even though some of them are transcribed by RNA polymerase (pol) II and others by pol III. As a result, the snRNA genes have served as a model system to explore how RNA polymerase specificity is determined and, in general, to compare the pol II and III transcription machineries. This has led to the concept that the pol II and III transcription machineries use common factors, the best known of which is the TATA box binding protein (TBP). In addition, the relative simplicity of these promoters has also made them an attractive system to study how transcriptional activators perform their function.

Item Type: Paper
Uncontrolled Keywords: POLYMERASE-III TRANSCRIPTION SELENOCYSTEINE TRANSFER-RNA U6 SNRNA GENE SPH-BINDING-FACTOR OCT-1 POU DOMAIN MOLECULAR-CLONING ACTIVITY REQUIRES PROMOTER ELEMENT BASAL PROMOTER FACTOR-TFIIIB
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transcription
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > snRNA
CSHL Authors:
Communities: CSHL labs > Hernandez lab
Depositing User: Matt Covey
Date: July 2001
Date Deposited: 21 Jan 2014 15:53
Last Modified: 21 Jan 2014 15:53
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29247

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