Favorable effect on neuronal viability in the anterior cingulate gyrus due to long-term treatment with atypical antipsychotics: an MRSI study

Braus, D. F., Ende, G., Weber-Fahr, W., Demirakca, T., Henn, F. A. (November 2001) Favorable effect on neuronal viability in the anterior cingulate gyrus due to long-term treatment with atypical antipsychotics: an MRSI study. Pharmacopsychiatry, 34 (6). pp. 251-3. ISSN 0176-3679 (Print)0176-3679 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/11778146
DOI: 10.1055/s-2001-18037

Abstract

In the present study, we evaluated 23 chronic schizophrenic patients under stable clinical conditions to determine the association between neuronal viability, as measured by in vivo(1)H magnetic resonance spectroscopic imaging (MRSI), and antipsychotic drug effects in the anterior cingulate cortex. Careful screening of the medication history showed that 11 of these patients had been treated with traditional neuroleptics only, while the others had switched to atypical antipsychotics due to non-response to traditional drugs. The group of patients receiving typical neuroleptic medication showed a mean NAA that was lower than in the group of patients receiving atypical antipsychotic drugs. Removing the duration of illness effect indicated a significant correlation between the NAA signal in the anterior cingulate gyrus and time on atypical drugs in patients under long-term atypical antipsychotic treatment. In contrast, patients with traditional medication revealed progressive decrease in the NAA level. These results suggest a favorable effect on neuronal viability in the anterior cingulate gyrus due to long-term treatment with atypical antipsychotics.

Item Type: Paper
Uncontrolled Keywords: Adult Antipsychotic Agents/ therapeutic use Cell Survival/drug effects Cross-Sectional Studies Female Gyrus Cinguli/ cytology Humans Magnetic Resonance Spectroscopy Male Middle Aged Neurons/ cytology Protons Schizophrenia/ drug therapy/pathology
Subjects: diseases & disorders > mental disorders > mood disorders
Investigative techniques and equipment > spectroscopy > magnetic resonance spectroscopy
CSHL Authors:
Communities: CSHL labs > Henn lab
Depositing User: Matt Covey
Date: November 2001
Date Deposited: 22 Jan 2014 19:49
Last Modified: 22 Jan 2014 19:49
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29222

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