Protein tyrosine phosphatases: a diverse family of intracellular and transmembrane enzymes

Fischer, E. H., Charbonneau, H., Tonks, N. K. (July 1991) Protein tyrosine phosphatases: a diverse family of intracellular and transmembrane enzymes. Science, 253 (5018). pp. 401-406. ISSN 0036-8075

URL: http://www.ncbi.nlm.nih.gov/pubmed/1650499
DOI: 10.1126/science.1650499

Abstract

Protein tyrosine phosphatases (PTPs) represent a diverse family of enzymes that exist as integral membrane and nonreceptor forms. The PTPs, with specific activities in vitro 10 to 1000 times greater than those of the protein tyrosine kinases would be expected to effectively control the amount of phosphotyrosine in the cell. They dephosphorylate tyrosyl residues in vivo and take part in signal transduction and cell cycle regulation. Most of the transmembrane forms, such as the leukocyte common antigen (CD45), contain two conserved intracellular catalytic domains; but their external segments are highly variable. The structural features of the transmembrane forms suggest that these receptor-linked PTPs are capable of transducing external signals; however, the ligands remain unidentified. A hypothesis is proposed explaining how phosphatases might act synergistically with the kinases to elicit a full physiological response, without regard to the state of phosphorylation of the target proteins.

Item Type: Paper
Uncontrolled Keywords: LEUKOCYTE-COMMON ANTIGEN EPIDERMAL GROWTH-FACTOR SERINE-THREONINE KINASE RABBIT SKELETAL-MUSCLE CELL-CYCLE CONTROL CHICKEN-EMBRYO FIBROBLASTS XENOPUS-LAEVIS OOCYTES ROUS-SARCOMA VIRUS PHOSPHOTYROSYL-PROTEIN HUMAN-PLACENTA
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > protein phosphatase
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
CSHL Authors:
Communities: CSHL labs > Tonks lab
Depositing User: Matt Covey
Date: July 1991
Date Deposited: 17 Dec 2013 15:42
Last Modified: 17 Dec 2013 15:42
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29093

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