The life cycle of Ca2+ ions in dendritic spines

Sabatini, B. L., Oertner, T. G., Svoboda, K. (January 2002) The life cycle of Ca2+ ions in dendritic spines. Neuron, 33 (3). pp. 439-452. ISSN 0896-6273

URL: http://www.ncbi.nlm.nih.gov/pubmed/11832230
DOI: 10.1016/S0896-6273(02)00573-1

Abstract

Spine Ca2+ is critical for the induction of synaptic plasticity, but the factors that control Ca2+ handling in dendritic spines under physiological conditions are largely unknown. We studied [Ca2+] signaling in dendritic spines of CA1 pyramidal neurons and find that spines are specialized structures with low endogenous Ca2+ buffer capacity that allows large and extremely rapid [Ca2+] changes. Under physiological conditions, Ca2+ diffusion across the spine neck is negligible, and the spine head functions as a separate compartment on long time scales, allowing localized Ca2+ buildup during trains of synaptic stimuli. Furthermore, the kinetics of Ca2+ sources governs the time course of [Ca2+] signals and may explain the selective activation of long-term synaptic potentiation (LTP) and long-term depression (LTD) by NMDA-R-mediated synaptic Ca2+.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > calcium channel
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells > dendritic spines
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells > dendritic spines
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells > dendritic spines

organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > synaptic plasticity
CSHL Authors:
Communities: CSHL labs > Svoboda lab
Depositing User: Matt Covey
Date: January 2002
Date Deposited: 31 Oct 2013 15:53
Last Modified: 31 Oct 2013 15:53
Related URLs:
URI: http://repository.cshl.edu/id/eprint/28780

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