Chromosomal rearrangements associated with morphological mutants provide a means for genetic variation of Candida albicans

Rustchenko-Bulgac, E. P., Sherman, F., Hicks, J. B. (1990) Chromosomal rearrangements associated with morphological mutants provide a means for genetic variation of Candida albicans. Journal of Bacteriology, 172 (3). pp. 1276-1283. ISSN 00219193 (ISSN)

URL: http://www.ncbi.nlm.nih.gov/pubmed/2407719

Abstract

At frequencies as high as 1.4%, the pathogenic yeast Candida albicans spontaneously gave rise to morphological mutants exhibiting more than 20 different types of abnormal colonies; approximately two-thirds of the mutants were stable, while the other one-third were unstable and produced mixtures of different colonial forms at very high rates. Abnormal electrophoretic karyotypes were observed for all of the 14 mutants that were examined, indicating that they were associated with different types of single and multiple gross chromosomal rearrangements. Because C. albicans is asexual and does not go through a meiotic cycle, we suggest that the high frequency of chromosomal rearrangements provides a means for genetic variation in this organism.

Item Type: Paper
Uncontrolled Keywords: article candida albicans chromosome rearrangement fungus genetic engineering genetic variability morphology nonhuman priority journal yeast mutant Chromosomes, Fungal DNA, Fungal Electrophoresis Karyotyping Mutation Nucleic Acid Hybridization Support, U.S. Gov't, P.H.S. Variation (Genetics) Fungi
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > mutations
organism description > yeast
CSHL Authors:
Communities: CSHL labs > Hicks lab
Depositing User: Matt Covey
Date: 1990
Date Deposited: 09 Aug 2013 20:55
Last Modified: 12 Aug 2013 14:49
Related URLs:
URI: http://repository.cshl.edu/id/eprint/28503

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