Rustchenko-Bulgac, E. P., Sherman, F., Hicks, J. B.
(1990)
Chromosomal rearrangements associated with morphological mutants provide a means for genetic variation of Candida albicans.
Journal of Bacteriology, 172 (3).
pp. 1276-1283.
ISSN 00219193 (ISSN)
Abstract
At frequencies as high as 1.4%, the pathogenic yeast Candida albicans spontaneously gave rise to morphological mutants exhibiting more than 20 different types of abnormal colonies; approximately two-thirds of the mutants were stable, while the other one-third were unstable and produced mixtures of different colonial forms at very high rates. Abnormal electrophoretic karyotypes were observed for all of the 14 mutants that were examined, indicating that they were associated with different types of single and multiple gross chromosomal rearrangements. Because C. albicans is asexual and does not go through a meiotic cycle, we suggest that the high frequency of chromosomal rearrangements provides a means for genetic variation in this organism.
| Item Type: |
Paper
|
| Uncontrolled Keywords: |
article
candida albicans
chromosome rearrangement
fungus
genetic engineering
genetic variability
morphology
nonhuman
priority journal
yeast mutant
Chromosomes, Fungal
DNA, Fungal
Electrophoresis
Karyotyping
Mutation
Nucleic Acid Hybridization
Support, U.S. Gov't, P.H.S.
Variation (Genetics)
Fungi |
| Subjects: |
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > mutations
organism description > yeast |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Hicks lab |
| Depositing User: |
Matt Covey
|
| Date: |
1990 |
| Date Deposited: |
09 Aug 2013 20:55 |
| Last Modified: |
12 Aug 2013 14:49 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/28503 |
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