PTEN plasticity: how the taming of a lethal gene can go too far

Naguib, A., Trotman, L. C. (2013) PTEN plasticity: how the taming of a lethal gene can go too far. Trends In Cell Biology, 23 (8). pp. 374-379. ISSN 0962-8924

URL: http://www.ncbi.nlm.nih.gov/pubmed/23578748
DOI: 10.1016/j.tcb.2013.03.003

Abstract

PTEN loss drives many cancers and recent genetic studies reveal that often PTEN is antagonised at the protein level without alteration of DNA or RNA expression. This scenario can already cause malignancy, because PTEN is haploinsufficient. We here review normally occurring mechanisms of PTEN protein regulation and discuss three processes where PTEN plasticity is needed: ischaemia, development, and wound healing. These situations demand transient PTEN suppression, whereas cancer exploits them for continuous proliferation and survival advantages. Therefore, increased understanding of PTEN plasticity may help us better interpret tumour development and ultimately lead to drug targets for PTEN supporting cancer therapy.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > PTEN
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
CSHL Authors:
Communities: CSHL Post Doctoral Fellows
CSHL labs > Trotman lab
CSHL Cancer Center Shared Resources > Animal Services
Depositing User: Matt Covey
Date: 2013
Date Deposited: 22 May 2013 19:44
Last Modified: 26 Dec 2014 15:13
PMCID: PMC3728179
Related URLs:
URI: http://repository.cshl.edu/id/eprint/28314

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