Carcinoma-associated fibroblasts in different tumor microenvironments.

Egeblad, M., Ewald, A. J., Askautrud, H. A., Truitt, M. L., Welm, B. E., Bainbridge, E., Peeters, G., Krummel, M. F., Werb, Z. (2008) Carcinoma-associated fibroblasts in different tumor microenvironments. [Video]

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Abstract

Three microenvironments were imaged in the same mouse before and after injection of dextran. Left panel: Most fibroblast specific protein1 (FSP1)+ cells (green) are non-migratory in the adipogenic stroma at the border of a hyperplastic lesion (blue). Middle panel: a few migratory FSP1+ cells are seen at the border of an early carcinoma (blue) among non-migratory FSP1+ and FSP1+/dextran+ cells. Right panel: Most FSP1+ cells that have infiltrated the carcinoma mass are non-migratory. Imaged in an MMTV-PyMT;ACTB-ECFP;Fsp1+.+.EGFP mouse injected intravenously 1 hours 41 minutes after imaging was initiated with rhodamine-conjugated dextran (red) to mark first blood vessels and then macrophages (FSP1+/dextran+; green/red). From Egeblad et al. (2008) Dis. Model. Mech., 1 155-167.

Item Type: Video
Subjects: diseases & disorders > cancer
diseases & disorders
Investigative techniques and equipment
Investigative techniques and equipment > microscopy > flourescence microscopy
Investigative techniques and equipment > microscopy > immunoflourescence microscopy
Investigative techniques and equipment > microscopy
CSHL Authors:
Communities: CSHL labs > Egeblad lab
Depositing User: Matt Covey
Date: 2008
Date Deposited: 26 Apr 2013 16:25
Last Modified: 26 Apr 2013 16:25
Related URLs:
URI: http://repository.cshl.edu/id/eprint/28264

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